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To a solution of anhydrous 9-iodominocycline freebase (204 g, 350 mmol), 4-methylphenylthiotributyltin (159 g, 385 mmol) and Pd(PPh 3) 4 (202 g, 175 mmol) in anhydrous DMF (175 mL) was bubbled CO for 15 minutes, then heated to 70°C with a large balloon of CO affixed to the flask to maintain a positive pressure of CO?
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